مجله زیست شناسی ایران

مروری بر ویژگی های ساختاری و عملکردی سلول های سرتولی بیضه

نوع مقاله : مقاله ترویجی

نویسندگان

1 دانشکده زیست فناوری، دانشگاه تخصصی فناوری های نوین آمل

2 دانشکده زیست فناوری دانشگاه تخصصی فناوریهای نوین آمل، ایران

3 گروه آناتومی و بیولوژی سلولی، مرکز تحقیقات ایمنوژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران

چکیده

واحد عملکردی تولید مثلی جنس مذکر در پستانداران بیضه است که با دارا بودن ویژگی‌های شیمیایی و فیزیکی ویژه‌ای توان تولید‌مثلی مذکر را بیان می‌کند ؛ هر بیضه در پستانداران از لوله‌های پیچیده تشکیل شده که از نظر مورفولوژیکی و فیزیولوژیکی به بخش های عملکردی متفاوت تقسیم می‌شود که هر کدام از این بخش‌ها شامل سلول‌های تخصص یافته‌ای هستند که امروزه هر کدام در شاخه‌های بسیار مهم تحقیقاتی حائز اهمیت‌اند ؛ در این مقاله سعی برآن داشتیم که سلول‌هایی سوماتیکی و ویژه‌ای به نام سلول‌های سرتولی را مورد بحث و بررسی قرار دهیم ؛ این سلول ها بخشی از لوله های اسپرم‌ساز‌اند که از بخش پایه (بازال) تا لومن آن کشیده شده است و مانند چادری سراسر لوله های اسپرم ساز را می پوشانند که این فرم مورفولوژیکی قطعا با نقش های عملکردی و فیزیولوژیکی آن ها مرتبط است ؛ نکته جالب و مورد توجه که به عنوان پایه و اساس بسیاری از تحقیقات انجام شده روی این سلول هاست، عدم تقسیم پذیری سلول های سرتولی در نیش خود است اما می توان پس از استخراج آن ها، به روش های متفاوتی مانند پلیت کردن با لکتین (به دلیل تمایل اتصال آن ها به لکتین بعد از هضم آنزیمی بافت بیضه) در محیط کشت های ویژه و شرایط آزمایشگاهی، آن ها را وادار به تقسیم کرد که این با توجه به نقش های اساسی در حمایت فیزیکی و شیمیایی از سلول های جنسی ، طی مراحل اسپرماتوژنز ، می تواند آینده ای روشن را در حل مشکلات ناباروری رقم بزند.

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مجله زیست شناسی ایران
دوره 5، شماره 9 - شماره پیاپی 9
شهریور 1400
صفحه 77-88
  • تاریخ دریافت: 08 اردیبهشت 1398
  • تاریخ بازنگری: 29 اردیبهشت 1398
  • تاریخ پذیرش: 29 اردیبهشت 1398